| 发明名称 |
ENZYMATIC MODIFICATION OF ANTI-AQP4 AUTOANTIBODY FOR MODULATING NEUROMYELITIS OPTICA |
| 摘要 |
Provided herein is a method of treating neuromyelitis optica (NMO) in an animal or human subject comprising administering to the subject a composition comprising a therapeutically effective amount of an Fc region modified anli-AQP4 antibody, thereby treating the NMO in the subject, in some embodiments, the Fc region modified anti-AQP4 antibody is an anti-AQP4 antibody deglycosylated at the amino acid position Asn297. In other embodiments, the Fc region modified anti-AQP4 antibody is an anii-AQP4 antibody F(ab′)2 fragment. |
| 申请公布号 |
US2015139981(A1) |
申请公布日期 |
2015.05.21 |
| 申请号 |
US201314402579 |
申请日期 |
2013.05.21 |
| 申请人 |
The Regents of the University of California |
发明人 |
Verkman Alan S.;Tradtrantip Lukmanee |
| 分类号 |
C07K16/28;A61K38/47;A61K39/395 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating neuromyelitis optica (NMO) in an animal or human subject comprising administering to the subject a composition comprising a therapeutically effective amount of an Fc region modified anti-AQP4 antibody, thereby treating the NMO in the subject. |
| 地址 |
Oakland CA US |
