PATHWAY RECOGNITION ALGORITHM USING DATA INTEGRATION ON GENOMIC MODELS (PARADIGM)

摘要

A patient sample specific dynamic pathway map is constructed on the basis of measured patient data and a probabilistic pathway model that is based on attributes for pathway elements, wherein some attributes for pathway elements are known a priori, where other attributes for the pathway elements are assumed, and where the pathway elements are cross-correlated and assigned an influence level for at least one pathway. Preferred dynamic pathway maps provide context of the measured patient data with respect to a selected reference pathway activity.

主权项

1. A method of analyzing biologically relevant information, comprising:
providing access to a pathway database storing a plurality of pathways, wherein at least one of the pathways has an a priori known association with a neoplastic disease;
wherein each of the plurality of pathways comprises a plurality of respective a priori known pathway elements, and wherein at least some of the a priori known pathway elements have an assumed or previously determined attribute; providing access to a modification engine coupled to the pathway element database; associating, via the modification engine, at least some of the pathway elements with at least one measured attribute, respectively, wherein the measured attribute is obtained from a patient sample; determining, via the modification engine, statistically a deregulation score for the at least some of the pathway elements based on the respective measured attributes and assumed or previously determined attributes; and updating, via the modification engine, a patient sample record using the deregulation score for the at least some of the pathway elements.