| 发明名称 |
Therapeutic Biologic for Treatment of Hepatocellular Carcinoma |
| 摘要 |
The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions. |
| 申请公布号 |
US2015140021(A1) |
申请公布日期 |
2015.05.21 |
| 申请号 |
US201414539577 |
申请日期 |
2014.11.12 |
| 申请人 |
China Synthetic Rubber Corporation |
发明人 |
Kao Kuo-Jang;Wang Yun-Hsin |
| 分类号 |
C07K16/18;C07K14/745 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A conjugate comprising a coagulating agent conjugated to an antibody, wherein the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP. |
| 地址 |
Taipei City TW |
