| 发明名称 | Transaminase polypeptides | ||
| 摘要 | The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds. | ||
| 申请公布号 | US9029106(B2) | 申请公布日期 | 2015.05.12 |
| 申请号 | US201313920902 | 申请日期 | 2013.06.18 |
| 申请人 | Codexis, Inc. | 发明人 | Dhawan Ish K.;Miller Gregory;Zhang Xiyun |
| 分类号 | C12N9/10;C12P13/00;C12P41/00 | 主分类号 | C12N9/10 |
| 代理机构 | Codexis, Inc. | 代理人 | Codexis, Inc. |
| 主权项 | 1. An engineered transaminase enzyme comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:2 and has an amino acid residue substitution at X153, wherein the enzyme has transaminase activity. | ||
| 地址 | Redwood City CA US | ||