| 发明名称 |
MODEL MOUSE OF ACUTE MYELOID LEUKEMIA (AML) HAVING ISOCITRIC DEHYDROGENASE (IDH) MUTATION |
| 摘要 |
<p>PROBLEM TO BE SOLVED: To express a disease state of AML depending on an IDH1 or IDH2 genetic mutation.SOLUTION: A model mouse developing AML is made by transducing four mutated genes (NPMc, IDH2/R140Q, DNMT3A/R882H and FLT3/ITD) into a mouse bone marrow cell and then transplanting the transduced cell to a mouse.</p> |
| 申请公布号 |
JP2015089359(A) |
申请公布日期 |
2015.05.11 |
| 申请号 |
JP20130230472 |
申请日期 |
2013.11.06 |
| 申请人 |
NATIONAL CANCER CENTER |
发明人 |
KITABAYASHI KAZUO;OGAWARA YOKO |
| 分类号 |
A01K67/027;C12Q1/02;G01N33/15;G01N33/50 |
主分类号 |
A01K67/027 |
| 代理机构 |
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