| 主权项 |
1. A method of treating cancer in a subject in need thereof, comprising administering to the subject an effective amount of a compound according to the structural formula: or a pharmaceutically acceptable salt thereof; wherein: R1 is H, OR12 or C1-C3 alkyl; R2 is OR12 or halo; R3 is H, C1-C6 alkyl or C3-C6 cycloalkyl; m is 0 or 1; R7 is phenyl, S(O)pR10, OR10, N(R10)2 or ═NN(R10)2; R5 and R6 are individually hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, 5-7 membered heterocyclyl, phenyl, benzyl, 5-7 membered heteroaryl, —N(R12)2, —C(O)R12, —C(O)OR12, —S(O)pR12, or —S(O)pN(R12)2, wherein each R5 and R6 that is not hydrogen is optionally and independently substituted with one or more R20; or R5 and R6, taken together with the nitrogen to which they are attached, form a 5-7 membered heterocyclyl which is optionally substituted with one or more R20; each R10 is independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, 5-14 membered heterocyclyl, C6-C20 aryl, 5-14 membered heteroaryl, —OR12, —N(R12)2, —C(O)R12, —C(O)OR12, —C(S)R12, —C(O)SR12, —C(O)N(R12)2, —C(S)N(R12)2, —C(NR12)OR12, —C(NR12)R12, —C(NR12)N(R12)2, —C(NR12)SR12, —S(O)pR12, —S(O)pOR12 or —S(O)pN(R12)2, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl represented by R10 are independently and optionally substituted by one or more R20; or two R10 moieties attached to the same nitrogen atom are taken together to form a 5-14 membered heterocyclyl or a 5-14 membered heteroaryl, each of which are optionally and independently substituted with one or more R20; each R12 is independently H, C1-C3 alkyl, C2-C3 alkenyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, C3-C7 cycloalkyl, phenyl, or benzyl, wherein each R12 with at least one hydrogen atom is optionally substituted with one or more R20; or two R12 substituents that are attached to the same atom or adjacent atoms, taken together with the atom(s) to which they are attached, form a 5-7 membered heterocyclyl or C3-C7 cycloalkyl which are each optionally and independently substituted with one or more R20; and each R20 is independently selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, 5-14 membered heterocyclyl, C6-C20 aryl, 5-14 membered heteroaryl, C3-C7 cycloalkyl-(C1-C3)alkyl, 5-14 membered heterocyclyl-(C1-C3)alkyl, C6-C20 aryl-(C1-C3)alkyl, 5-14 membered heteroaryl-(C1-C3)alkyl, halo, cyano, nitro, azido, —N(R12)2, —OR12, —C(O)R12, —C(O)OR12, —C(S)R12, —C(O)SR12, —C(S)SR12, —C(S)OR12, —C(O)N(R12)2, —C(S)N(R12)2, —C(NR12)OR12, —C(NR12)R12, —C(NR12)N(R12)2, —C(NR12)SR12, —OC(O)N(R12)2, —OC(O)R12, —OC(O)OR12, —OC(S)OR12, —OC(NR12)OR12, —SC(O)R12, —SC(O)OR12, —SC(NR12)OR12, —OC(S)R12, —SC(S)R12, —SC(S)OR12, —OC(O)N(R12)2, —OC(S)N(R12)2, —OC(NR12)N(R12)2, —SC(O)N(R12)2, —SC(NR12)N(R12)2, —SC(S)N(R12)2, —OC(NR12)R12, —SC(NR12)R12, NR12C(O)R12, NR12C(S)R12, NR12C(S)OR12, —NR12C(NR12)R12, —NR12C(O)OR12, —NR12C(NR12)OR12, —NR12C(O)N(R12)2, —NR —NR12C(NR12)N(R12)2, —S(O)pR12, —OS(O)pR12, —OS(O)pOR12, —OS(O)pN(R12)2, —S(O)pOR12, —NR12S(O)pR12, —NR12S(O)pN(R12)2, —NR—S(O)pN(R12)2, —SS(O)pR12, —SS(O)pOR12, —SS(O)pN(R12)2, —OP(O)(OR12)2, or —SP(O)(OR12)2, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteroaralkyl represented by R20 are each optionally and independently substituted with one to three groups from halo, C1-C3 alkyl, phenyl, benzyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3haloalkoxy, nitro, cyano, azido, amino and C1-C5 carbamoyl; or two R20 moieties attached to the same atom form an oxo (═O), thioxo (═S) or imino (═NR12); provided that one of R1 and R3 is hydrogen. |
