发明名称 |
Methods of administering and evaluating nitrogen scavenging drugs for the treatment of hepatic encephalopathy |
摘要 |
The present disclosure provides methods for treating hepatic encephalopathy (HE) and for optimizing and adjusting nitrogen scavenging drug dosage for subjects with HE, comprising administering a nitrogen scavenging drug at a dosage sufficient to maintain a. fasting blood ammonia level at or below a specified threshold level which is 1.5 times the upper limit of normal for blood ammonia. The nitrogen scavenging drug administered in the method is a phenylacetic acid prodrug selected from HPN-100, PBA, NaPBA, sodium benzoate, or any combination thereof (i.e., any combination of two or more of HPN-100, PBA, NaPBA). |
申请公布号 |
AU2013347905(A1) |
申请公布日期 |
2015.04.30 |
申请号 |
AU20130347905 |
申请日期 |
2013.11.21 |
申请人 |
MOKHTARANI, MASOUD;HYPERION THERAPEUTICS, INC.;SCHARSCHMIDT, BRUCE |
发明人 |
SCHARSCHMIDT, BRUCE;MOKHTARANI, MASOUD |
分类号 |
A61K49/00;A61K31/19 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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