SYSTEM AND METHOD FOR PROCESSING GENOTYPE INFORMATION RELATING TO DRUG METABOLISM

摘要

There are systems and methods for performing an assay to generate genotype information about a subject associated with a medical condition. There are also systems and method for generating and utilizing prognostic information associated with treating the patient with a medication based on the genotype information and an association of the genotype and metabolizing the medication. The genotype information includes data relating to SNP alleles in the patient's genotype and the association of the alleles and metabolism of a medication by the patient.

主权项

1. A system for performing an assay, comprising:
a sample interface configured to present a sample of human genetic material of a patient associated with having a medical condition, the patient having a genotype; and a detector configured for detecting in the sample a presence of at least five polymorphisms in the genotype to determine an assay result comprising data describing a presence or an absence of the polymorphisms, wherein the polymorphisms are selected from a group consisting of:
a T allele at the marker of SEQ ID No: 1 in the CYP2C9 gene,a C allele at the marker of SEQ ID No: 2 in the CYP2C9 gene,a C allele at the marker of SEQ ID No: 3 in the CYP2C9 gene,a G allele at the marker of SEQ ID No: 4 in the CYP2C9 gene,a deletion allele at the marker of SEQ ID No: 5 in the CYP2C9 gene,an A allele at the marker of SEQ ID No: 6 in the CYP2C19 gene,an A allele at the marker of SEQ ID No: 7 in the CYP2C19 gene,a G allele at the marker of SEQ ID No: 8 in the CYP2C19 gene,a T allele at the marker of SEQ ID No: 9 in the CYP2C19 gene,an A allele at the marker of SEQ ID No: 10 in the CYP2C19 gene,an A allele at the marker of SEQ ID No: 11 in the CYP2C19 gene,a C allele at the marker of SEQ ID No: 12 in the CYP2C19 gene,a G allele at the marker of SEQ ID No: 13 in the CYP2D6 gene,a deletion allele at the marker of SEQ ID No: 14 in the CYP2D6 gene,an A allele at the marker of SEQ ID No: 15 in the CYP2D6 gene,a deletion allele at the marker of SEQ ID No: 16 in the CYP2D6 gene,a C allele at the marker of SEQ ID No: 17 in the CYP2D6 gene,a T allele at the marker of SEQ ID No: 18 in the CYP2D6 gene,a deletion allele at the marker of SEQ ID No: 19 in the CYP2D6 gene,a T allele at the marker of SEQ ID No: 20 in the CYP2D6 gene,a C allele at the marker of SEQ ID No: 21 in the CYP2D6 gene,an A allele at the marker of SEQ ID No: 22 in the CYP2D6 gene,an AA allele at the marker of SEQ ID No: 23 in the CYP2D6 gene,a T allele at the marker of SEQ ID No: 24 in the CYP2D6 gene,a AGTGGGCAC allele at the marker of SEQ ID No: 25 in the CYP2D6 gene,a T allele at the marker of SEQ ID No: 26 in the CYP2D6 gene,an A allele at the marker of SEQ ID No: 27 in the CYP2D6 gene,an A allele at the marker of SEQ ID No: 28 in the CYP2D6 gene,a C allele at the marker of SEQ ID No: 29 in the CYP2D6 gene,an A allele at the marker of SEQ ID No: 30 in the CYP2D6 gene,a G allele at the marker of SEQ ID No: 31 in the CYP3A4 gene,an A allele at the marker of SEQ ID No: 32 in the CYP3A5 gene,an A allele at the marker of SEQ ID No: 33 in the VKORC1 gene,a T allele at the marker of SEQ ID No: 34 in the VKORC1 gene,a G allele at the marker of SEQ ID No: 35 in the VKORC1 gene,a C allele at the marker of SEQ ID No: 36 in the VKORC1 gene,a T allele at the marker of SEQ ID No: 37 in the VKORC1 gene,an A allele at the marker of SEQ ID No: 38 in the VKORC1 gene,an A allele at the marker of SEQ ID No: 39 in the CYP1A2 gene, anda C allele at the marker of SEQ ID No: 40 in the CYP3A7 gene.