Solid support with a grafted chain

摘要

Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.

主权项

1. An article comprising a (meth)acryloyl-functionalized support of Formula (II)
SS-(CO)—NH—C(R1)2—(CH2)p—(CO)-Q-Y1-Q-(CO)—CR2═CH2  (II) wherein
SS is a solid support;p is an integer equal to 0 or 1;each R1 is independently selected from alkyl, heteroalkyl, aryl, or aralkyl;each Q is independently a divalent group selected from oxy, thio, or —NR3— where R3 is hydrogen, alkyl, heteroalkyl, aryl, or aralkyl;Y1 is a first linking group that comprises an alkylene, heteroalkylene, arylene, or combination thereof; andeach R2 is independently hydrogen or an alkyl.