Spatial Modulation of Magnetic Particles in Vasculature by External Magnetic Field

摘要

A method for modulating a response signal includes introducing functionalized magnetic particles configured to interact with target analytes into the body, applying a magnetic field sufficient to draw the functionalized magnetic particles towards a surface of the lumen of subsurface vasculature closest to an internally or externally applied mask having a spatial arrangement, and detecting a response signal, which includes a background signal and an analyte response signal, transmitted from the subsurface vasculature. The analyte response signal related to interaction of the functionalized magnetic particles with the target analytes and is modulated with respect to the background signal due, at least in part, to the spatial arrangement of the mask. The target analytes may be non-invasively detected by differentiating the analyte response signal from the background signal due, at least in part, to the modulation of the analyte response signal.

主权项

1. A method, comprising:
applying a magnetic field sufficient to distribute magnetic particles present in a body into a spatial arrangement in a lumen of subsurface vasculature; detecting a response signal transmitted from the subsurface vasculature, wherein the response signal includes a background signal and an analyte response signal related to interaction of functionalized particles present in the body with the one or more target analytes, and wherein the analyte response signal is modulated with respect to the background signal due, at least in part, to the spatial arrangement of the magnetic particles; and non-invasively detecting the one or more target analytes by differentiating the analyte response signal from the background signal due, at least in part, to the modulation of the analyte response signal.