HEXON ISOLATED FROM SIMIAN ADENOVIRUS SEROTYPE 19, HYPERVARIABLE REGION THEREOF AND CHIMERIC ADENOVIRUS USING THE SAME

摘要

Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.

主权项

1. A chimeric adenovirus comprising a nucleic acid of a first serotype adenovirus and a nucleic acid of a second serotype adenovirus, said first serotype being different from said second serotype, wherein the nucleic acid of the second serotype adenovirus replaces a part of the nucleic acid of the first serotype adenovirus, which part encodes a hexon of the first serotype adenovirus; and wherein the nucleic acid of the second serotype adenovirus encodes the amino acid sequence of SEQ ID NO: 16 or its fragment comprised of seven or more consecutive residues of SEQ ID NO: 16.