Use of functionalized magnetic nanoparticles in cancer detection and treatment

摘要

The present invention provides methods of detecting a cancer cell in an individual, methods of grading a cancer, and methods of treating a cancer. The methods involve use of functionalized magnetic nanoparticles that comprise a moiety that provides for selective association with, and/or metabolic uptake into, a cancer cell.

主权项

1. A method of detecting a cancer cell in an individual, the method comprising
a) administering to the individual a pharmaceutical composition comprising:
i) a functionalized magnetic nanoparticle (MNP) of the formula M-S-(L)-Z, wherein M is a magnetic core, S is a polymer, L is an optional linker, and Z is a functional moiety that has differential affinity for and/or metabolic uptake into a cancer cell,wherein the functional moiety is corticotropin releasing hormone, and wherein the cancer cell is a pituitary tumor cell;wherein the functional moiety is adrenocorticotropin hormone, and wherein the cancer cell is an adrenal dysplasia or tumor; orwherein the functional moiety is 2-deoxyglucose (2DG) and wherein the 2DG is linked via the 6-OH group of the 2DG; andii) a pharmaceutically acceptable carrier; and b) detecting the functionalized MNP in association with the cancer cell.