| 发明名称 |
METHODS OF USING ISONIAZID FOR THE DIAGNOSIS OF LUNG INFECTIONS |
| 摘要 |
The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopic ally labeled isoniazid. |
| 申请公布号 |
US2015104819(A1) |
申请公布日期 |
2015.04.16 |
| 申请号 |
US201314404134 |
申请日期 |
2013.03.07 |
| 申请人 |
STC.UNM ;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
Timmins Graham;Choi Seong;Sharp Zachary;Atudorei Viorel;Maiga Mamoudou;Bishai William |
| 分类号 |
C12Q1/04;C12Q1/28 |
主分类号 |
C12Q1/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for determining the presence or absence of a bacterial infection in the lungs of a patient comprising:
administering to the lungs of the patient a diagnostically effective amount of 15N-labeled isoniazid and optionally, isotopically labeled urea; collecting one or more samples of exhaled breath from the subject; and determining the amount of 15N-labeled nitrogen gas in said samples; said amount indicating the presence or absence of the bacterial infection in the lungs of the patient. |
| 地址 |
Albuquerque NM US |
