发明名称 |
COMBINATION OF A 17 -ALPHA -HYDROXYLASE (C17, 20 - LYASE) INHIBITOR AND A SPECIFIC PI-3K INHIBITOR FOR TREATING A TUMOR DISEASE |
摘要 |
<p>The present invention relates to a combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor selected from the group consisting of a compound of formula (I) or a compound of formula (II), or pharmaceutically acceptable salt thereof, (b) a 17α-Hydroxylase/C17,20-lyase inhibitor (CYP17 inhibitor), specifically abiraterone acetate and 1-(2-Chloro-pyridin-4-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential use for the treatment of a tumor disease; a pharmaceutical composition comprising such combination; use of such combination for the treatment of a tumor disease; a commercial package or product comprising such combination; and to a method of treating a patient having a tumor disease comprising administration of said combination to a patient in need thereof.</p> |
申请公布号 |
EP2858631(A1) |
申请公布日期 |
2015.04.15 |
申请号 |
EP20130729566 |
申请日期 |
2013.06.04 |
申请人 |
NOVARTIS AG |
发明人 |
HIRAWAT, SAMIT;RIVA, ALESSANDRO;MISTRY, PRAKASH |
分类号 |
A61K31/00;A61K31/4745;A61K31/496;A61K31/506;A61K31/58;A61P35/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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