| 发明名称 | Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4 | ||
| 摘要 | The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sialidase 4 (NEU4), in particular, by targeting natural antisense polynucleotides of Sialidase 4 (NEU4). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of NEU4. | ||
| 申请公布号 | US8993533(B2) | 申请公布日期 | 2015.03.31 |
| 申请号 | US201113879100 | 申请日期 | 2011.10.05 |
| 申请人 | CuRNA, Inc. | 发明人 | Collard Joseph;Khorkova Sherman Olga |
| 分类号 | A61K48/00;C12N15/113;A61K31/7088;C12N9/24 | 主分类号 | A61K48/00 |
| 代理机构 | CuRNA, Inc. | 代理人 | CuRNA, Inc. ;Browder Monte R. |
| 主权项 | 1. A method of upregulating a function of and/or the expression of a Sialidase 4 (NEU4) polynucleotide selected from SEQ ID No: 1 in a biological system comprising: contacting said system with at least one antisense oligonucleotide 10 to 30 nucleotides in length wherein said at least one oligonucleotide specifically hybridizes to a natural antisense polynucleotide of the Neu4 polynucleotide and has at least 80% sequence identity to a 10 to 30 nucleotide region of a reverse complement of a natural antisense polynucleotide of the Sialidase 4 (NEU4) polynucleotide selected from nucleotides 1 to 2119 of SEQ ID NO: 2 or 1245 of SEQ ID NO: 3 or 1 to 490 of SEQ ID NO: 4 or 1 to 527 of SEQ ID NO: 5 or 1 to 946 of SEQ ID NO: 6 or 1 to 703 of SEQ ID NO 7; thereby upregulating a function of and/or the expression of the Sialidase 4 (NEU4) polynucleotide. | ||
| 地址 | Miami FL US | ||