Using Heavy Water as a Contrast Agent for Hydrogen Magnetic Resonance Imaging

摘要

A method of using an imaging contrast agent is provided for hydrogen magnetic resonance imaging (H MRI). The agent uses replacement and chemical exchange of hydrogen (H) and deuterium (D) on obtaining MRI images for comparison. An isotonic physiologic saline solution with deuterium oxide (D2O) is made. The solution is intravenously injected to obtain the intensity alterations on MRI images. The injected D2O is perfused into tissue and replace the original water. Exchanges between H and D occur and a solution of hydrogen deuterium oxide (HDO) is obtained. After such mechanisms, MRI images are compared for differences. Thus, a novel, non-radioactive, non-toxic and non-invasive MRI agent is provided for people who are allergic to general imaging agents.

主权项

1. A method of providing a fast, non-radioactive, non-toxic and non-invasive imaging contrast agent for use in perfusion MRI, comprising:
administering heavy water (deuterium oxide, D2O) as a contrast agent of hydrogen magnetic resonance imaging (MRI); and indirectly detecting the deuterium (D) by measuring the difference of signal intensities of hydrogen (1H) before and after administration of D2O.