发明名称 |
ENHANCED ARTEMISININ-BASED COMBINATION THERAPY FOR TREATING PARASITIC MEDIATED DISEASE |
摘要 |
The present invention describes a method of treating individuals suffering from microbial infections, including a parasitic disease such as malaria, by using an improved Artemisinin Combination Therapy (ACT), known as ActRx Tri-ACT Plus. The improved ACT therapy includes administering a combination of four drugs. In one embodiment of the present invention, the method includes administering to an individual a first composition comprising a therapeutically effective amount of an artemether spray sublingually. The individual is then administered a second composition, a therapeutically effective amount of artesunate. A third composition, an effective amount of berberine, or its pharmaceutically acceptable derivatives or salts is administered to the individual. A fourth composition, an effective amount of primaquine, or its pharmaceutically acceptable derivatives or salts is administered to the individual. |
申请公布号 |
WO2015041722(A1) |
申请公布日期 |
2015.03.26 |
申请号 |
WO2014US33555 |
申请日期 |
2014.04.09 |
申请人 |
KRYPTONITE GROUP, LTD;STEELE, ROBERT, LEWIS |
发明人 |
STEELE, ROBERT, LEWIS;MUSSO, ANTHONY, FEDELE;MUNDSCHENK, DAVID, D.;VAN DE CASTEELE, RUSSELL |
分类号 |
A61K31/4706;A61K9/00;A61K9/12;A61K31/357;A61K31/4375;A61P33/06 |
主分类号 |
A61K31/4706 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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