<p>A large caliber vertical pipe cleaning apparatus is disclosed. According to an embodiment of the present invention, the large caliber vertical pipe cleaning apparatus comprises: a guide unit which comes in contact with a passage portion having a pipe shape like a rudder trunk of a ship, and is arranged to move up and down along the passage portion; and a cleaning unit which is rotationally coupled to the guide unit and has a brush rotating by air pressure to clean the passage portion.</p>