Anti-CD11A Antibodies and Uses Thereof

摘要

Provided herein are isolated human, chimeric, and humanized antibodies and antigen-binding fragments thereof that specifically bind to CD11a. Also provided are methods of treating human immunodeficiency virus (e.g., reducing the risk of developing or preventing the development of HIV infection or AIDS) in a subject that has an HIV infection or AIDS that include administering at least one of the antibodies or antigen-binding fragments to the subject. Also provided are methods of crosslinking CD11a on the surface of a cell that include contacting the cell with at least one of the antibodies or antigen-binding fragments. Also provided are compositions (e.g., pharmaceutical compositions) containing at least one of the antibodies or antigen-binding fragments.

主权项

1. An isolated human, chimeric, or humanized antibody or antigen-binding fragment thereof, wherein the antibody or fragment thereof binds competitively with an antibody produced by the hybridoma deposited at the American Type Culture Collection (ATTC) and designated as HB 9579, and wherein the antibody or antigen-binding fragment thereof comprises a light chain variable domain comprising a contiguous sequence of at least five amino acids within the sequence of SEQ ID NO: 1, SEQ ID NO: 19, or SEQ ID NO: 20, or a heavy chain variable domain comprising a contiguous sequence of at least five amino acids within the sequence of SEQ ID NO: 2, SEQ ID NO: 21, or SEQ ID NO: 22.