| 摘要 |
The present invention provides a compound of formula (I):;
said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition. |
| 主权项 |
1. A compound of formula (II) wherein R′1 is selected from cycloakyl, R5C(O)—, R6SO2—, and (R8)(R9)N—, aryl, heteroaryl, heterocycloalkyl, said aryl, heteroaryl, and heterocycloalkyl are optionally substituted by one or two substituents selected from hydroxy, halo, alkyl, carboxyl, alkoxycarbonyl, and HC(O)—; wherein R4, R5, R6, R8 and R9 are independently alkyl or aryl each of which is optionally substituted by one to five substituents selected from the group consisting of (C1-C7) alkyl, halo, hydroxyl, (C1-C7) alkoxy, and aryl; R2 and R3 are independently hydrogen, or (C1-C7) alkyl; X is selected from cyano, halogen, nitro, alkyl-S—, alkyl-SO—, alkyl-SO2—, H2N—SO2—, R5—C(O)—, alkyl, and R4—O, wherein R4 and R5 are independently alkyl or aryl each of which is optionally substituted by substituents selected from the group consisting of (C1-C7) alkyl, halo, hydroxyl, (C1-C7) alkoxy, and aryl; or a pharmaceutically acceptable salt thereof, or an optical isomer thereof; or a mixture of optical isomers. |
