| 发明名称 |
Modulators of ATP-Binding Cassette Transporters |
| 摘要 |
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. |
| 申请公布号 |
US2015065500(A1) |
申请公布日期 |
2015.03.05 |
| 申请号 |
US201414484192 |
申请日期 |
2014.09.11 |
| 申请人 |
Vertex Pharmaceuticals Incorporated |
发明人 |
Hadida-Ruah Sara;Hamilton Matthew;Miller Mark;Grootenhuis Peter D.J.;Bear Brian;McCartney Jason;Zhou Jinglan;van Goor Frederick |
| 分类号 |
C07D405/12;C07D405/14;A61K31/4545;A61K31/5377;A61K45/06;A61K31/496;C07D413/14;A61K31/501;A61K31/506;G01N33/50;A61K31/443;A61K31/444 |
主分类号 |
C07D405/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound selected from Table 1, compounds 1-528. |
| 地址 |
Boston MA US |
