VASCULAR ENDOTHELIAL GROWTH FACTOR ANTAGONISTS AND METHODS FOR THEIR USE

摘要

The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.