Methods of treating pain using an IL-31 monoclonal antibody

摘要

Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.

主权项

1. A method of treating pain in a patient comprising administering to the patient a monoclonal antibody or an antigen-binding fragment thereof that specifically binds to a polypeptide sequence of amino acid residues 27-164 of SEQ ID NO:2, wherein after administration the patient's pain is reduced.