Analyte detection devices and methods with hematocrit-volume correction and feedback control

摘要

Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample.

主权项

1. An arrangement for measuring the concentration of an analyte contained in a sample of body fluid, the arrangement comprising:
an assay pad comprising only a single chemical reagent capable of producing a detectable signal in the form of a color change at a reaction spot formed upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value derived from the color change at the reaction spot indicative of the level of hematocrit contained in the sample, wherein the at least one value is derived from the rate of the color change; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample using the at least one value.