| 发明名称 |
NOVEL LIVE RECOMBINANT BOOSTER VACCINE AGAINST TUBERCULOSIS |
| 摘要 |
Embodiments of the invention comprise an improved vaccine for generating an immune response and preventing or treating mycobacterial diseases such as tuberculosis in humans and animals. Embodiments of the invention also comprise a method for using the vaccine against such mycobacterial diseases. |
| 申请公布号 |
US2015056242(A1) |
申请公布日期 |
2015.02.26 |
| 申请号 |
US201414520163 |
申请日期 |
2014.10.21 |
| 申请人 |
The Regents of the University of California |
发明人 |
Horwitz Marcus A.;Jia Qingmei |
| 分类号 |
A61K39/02;C07K14/35;C07K14/195;A61K39/04 |
主分类号 |
A61K39/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of generating an antibody to a Mycobacterium tuberculosis 30 kDa antigen 85B protein (SEQ ID NO: 4) comprising the steps of:
immunizing a mammal with Mycobacterium bovis strain Bacille Calmette-Guérin (BCG) in a primary immunization; immunizing a mammal with a composition of matter comprising attenuated Listeria monocytogenes in a booster immunization, wherein the Listeria monocytogenes: does not express a functional ActA protein (SEQ ID NO: 1); and expresses Mycobacterium tuberculosis 30 kDa antigen 85B protein (SEQ ID NO: 4); such that an antibody to a Mycobacterium tuberculosis 30 kDa antigen 85B protein is generated. |
| 地址 |
Oakland CA US |
