发明名称 |
THERAPEUTIC APYRASE CONSTRUCTS, APYRASE AGENTS, AND PRODUCTION METHODS |
摘要 |
<p>This invention provides a new class of enhanced apyrases (EN-apyrases) with superior pharmacokinetic, pharmacodynamic, and pharmacochemical properties and which can be purified using simplified procedures. The invention further provides constructs for transforming a cell to produce these EN-apyrases. The EN-apyrase construct comprises sequences encoding a signal sequence, a linker, and a soluble apyrase. Also provided are preparations of apyrases and methods for producing apyrase in culture cells and purification thereof.</p> |
申请公布号 |
EP2523971(B1) |
申请公布日期 |
2015.02.25 |
申请号 |
EP20110733394 |
申请日期 |
2011.01.13 |
申请人 |
APT THERAPEUTICS, INC. |
发明人 |
CHEN, RIDONG;JEONG, SOON, SEOG |
分类号 |
C07K14/435;C07K14/705;C12N9/14 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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