| 发明名称 |
CONJUGATES OF PLASMODIUM FALCIPARUM SURFACE PROTEINS AS MALARIA VACCINES |
| 摘要 |
Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against Plasmodium falciparum, the most severe form of malaria. Conjugates of ookinete surface protein Pvs25 for use as a vaccine against Plasmodium vivax are also provided. Methods for preparing the conjugates, which comprise the ookinete surface protein bound onto itself or onto another protein by a linking group, are also provided. |
| 申请公布号 |
US2015050314(A1) |
申请公布日期 |
2015.02.19 |
| 申请号 |
US201414527676 |
申请日期 |
2014.10.29 |
| 申请人 |
The United States of America as represented by the Secretary, Department of Health and Human Service |
发明人 |
Schneerson Rachel;Kubler-Kielb Joanna;Wu Yimin;Miller Louis;Majadly Fathy;Robbins John B. |
| 分类号 |
C07K14/445 |
主分类号 |
C07K14/445 |
| 代理机构 |
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代理人 |
|
| 主权项 |
1. A conjugate comprising a first protein that comprises a Plasmodium vivax surface protein Pfs25 bound to a second protein that comprises a Plasmodium vivax surface protein Pvs25, or a Pseudomonas aeruginosa recombinant exoprotein A. |
| 地址 |
Bethesda MD US |
