CURAXINS FOR USE IN TREATING BREAST CANCER AND METHOD FOR IDENTIFING PATIENTS LIKELY TO RESPOND

摘要

The present invention relates to the treatment of breast cancer which is estrogen receptor positive (ER+) and/or human epidermal growth factor receptor 2 positive (HER2) and/or progesterone receptor positive (PR) and/or facilitates chromatin transcription positive (FACT+) with a curaxin, including curaxin 137. The present invention also pertains to a method of identifying a subject who has a breast cancer tumor and is likely to respond to treatment with a curaxin.

主权项

1. A method for treating breast cancer in a subject in need thereof comprising administering an effective amount of a compound of Formula I:wherein:
each of R1-R9 are independently H, hydroxyl or alkyl; n is 0, 1, 2, 3, 4, or 5; or a pharmaceutically acceptable salt or hydrate thereof; and the breast cancer is one or more of estrogen receptor positive (ER+), human epidermal growth factor receptor 2 positive (HER2+), progesterone receptor positive (PR+), and facilitates chromatin transcription positive (FACT+).