| 摘要 |
Bi- and tri-aromatic compounds of the formula (I) wherein R1 to RIO and X are as defined, are Nox2 inhibitors that are useful as medicaments for the treatment of a disease or condition selected from: cardiovascular diseases, respiratory diseases, inflammatory diseases, cancers, ageing and age related disorders, kidney diseases, neurodegenerative diseases, diabetes and conditions associated with diabetes. The compounds, their preparation and pharmaceutical compositions comprising them are disclosed.; |
| 主权项 |
1. A compound of the formula (I)wherein
A1 and A2 are independently selected from: phenyl, pyridinyl, naphthyl and quinolinyl; A2 is substituted by at least two OH groups; and A1 and A2 are optionally substituted by one or more groups selected from: H, OR14, NR15R16, R17 and halogen; wherein R14, R15 and R16 are each independently selected from: H and alkyl; R17 is alkyl, aryl or arylalkyl, where each group is optionally substituted by one or more groups selected from: OR14, Nee and halogen, where R14, R15 and R16 are as defined; X is a 5 or 6-membered unsaturated, saturated or partially unsaturated carbocyclic or heterocyclic ring, wherein the heterocyclic ring has 1, 2, 3, or 4 heteroatoms selected from: O, N and S, or X is a group of the formula belowwherein
R11 is O, S or NH; and R12 and R13 are independently selected from: O, S, NH and CH2; in any stereochemical form, or a mixture of any stereochemical forms in any ratios; or a pharmaceutically acceptable salt, metabolite, prodrug, or a mixture thereof. |
