The disclosure describes replication competent retroviral vectors (RCR) for gene therapy and gene delivery. The RCR includes an IRES sequence having 6-7 A's in A-bulge of the bifurcation region. The disclosure provides recombinant replication competent retrovirus comprising: a retroviral GAG protein; a retroviral POL protein; a retroviral envelope; a retroviral polynucleotide comprising Long-Terminal Repeat (LTR) sequences at the 3' end of the retroviral polynucleotide sequence, a promoter sequence at the 5' end of the retroviral polynucleotide.
申请公布号
WO2015021077(A1)
申请公布日期
2015.02.12
申请号
WO2014US49831
申请日期
2014.08.05
申请人
TOCAGEN INC.
发明人
LIN, AMY, H.;GRUBER, HARRY, E.;IBANEZ, CARLOS;JOLLY, DOUGLAS, J.