Acrylic hydrogels with pendant cyclodextrins, preparation method thereof and use of same as release systems and contact lens components

摘要

The invention relates to acrylic hydrogels with pendant cyclodextrins, the preparation and application thereof as release systems and components of contact lenses. The method for obtaining acrylic hydrogels with pendant cyclodextrins is characterized in that the hydrogels are formed by a polymer lattice obtained by polymerization of mono- and bifunctional acrylic or methacrylic monomers and monomers having glycidyl groups in their structure, to which cyclodextrin units are covalently bound once formed; and the use and applications of the compositions in the preparation of contact lenses with the capacity for incorporating drugs, active substances or demulcents useful in the treatment of pathological or physiological conditions, in the production of topical, transdermal or transmucosal release systems for medicinal products or active substances, and in the preparation of cosmetics.

主权项

1. A contact lens for the release of drugs, active substances or demulcents comprising a hydrogel in the form of a three-dimensional network wherein the hydrogel is formed by cross-linked acrylic or methacrylic chains having alkyl groups to which cyclodextrins are bound by means of an ether bond, wherein the acrylic or methacrylic chains are formed from acrylic or methacrylic units having an alkyl ether group and wherein the proportion of the acrylic or methacrylic units containing an alkyl ether group is between 0.1% and 10% by weight of the hydrogel.