发明名称 |
Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for “cest” applications |
摘要 |
Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111). |
申请公布号 |
US8945512(B2) |
申请公布日期 |
2015.02.03 |
申请号 |
US200410552851 |
申请日期 |
2004.04.06 |
申请人 |
Bracco Imaging SpA |
发明人 |
Aime Silvio;Terreno Enzo;Delli Castelli Daniela;Giovenzana Giovanni Battista |
分类号 |
A61B5/055;A61B5/00;C07K1/00;C08B37/00;A61K49/08;A61K49/10;A61K49/14 |
主分类号 |
A61B5/055 |
代理机构 |
|
代理人 |
Alderson, Jr. Robert E. |
主权项 |
1. A method of imaging a subject comprising, administering to the subject a paramagnetic CEST agent comprising,
a substrate molecule (SH) comprising at least one mobile proton in exchange with bulk water bound by electrostatic interactions having a thermodynamic constant of association Ka greater than 10 to a paramagnetic chelate complex (SR) of a metal ion selected from the group consisting of: iron (II) (high-spin configuration), iron (III), cobalt (II), rhodium (II), copper (II), nickel (II), cerium (III), praseodymium (III), neodymium (III), dysprosium (III), erbium (III), terbium (III), holmium (III), thulium (III), ytterbium (III) and europium (III); applying an if pulse sufficient to saturate the resonance of the at least one mobile proton shifted from the bulk water as a result of said electrostatic interaction to create a saturated magnetization that is transferred to the bulk water through chemical exchange, and imaging the subject using a CEST-based MRI procedure. |
地址 |
Milan IT |