| 摘要 |
Peptides of the present invention have identical or similar function as natural interleukin (IL)-3 and have small sizes, thereby enhancing skin permeability. Also, the peptides of the present invention: inhibit activation of NF-B and nuclear transition by inhibiting receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling path; and density dependently inhibit differentiation of osteoclast by inhibiting expression of RANKL or inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or type 1 or type 2 TNF receptor. In addition, the peptides of the present invention promote expression of osteoclast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPN), bone sialoprotein (BSP) or osteopontin (OPN), thereby contributing to osteoclast differentiation. Therefore, the activities and stability of the peptides of the present invention can be usefully applied to medicines, sanitary aids, or cosmetics. |
