| 摘要 |
<p>PURPOSE: A composition controlling the differentiation into a dopaminergic neuronal cell by metaloprotease ADAM17 is provided to be able to obtain a therapeutic effect of diseases induced by the dopaminergic neuronal cell death by enabling to increase the dopaminergic neuron in the mesencephalon site, and to be able to enhance the therapeutic effect of diseases such as tumor by suppressing the activation. CONSTITUTION: A method of controlling the differentiation of a neuronal stem cell or a neuronal progenitor cell into a dopaminergic neuronal cell comprises a step of increasing or suppressing the activation of ADAM17 of a neuronal stem cell or a neuronal progenitor cell. A composition for accelerating the differentiation of a dopaminergic neuronal cell includes an activator of ADAM17 as an active ingredient. A composition for treatment of brain-nerve system diseases includes an activator or inhibitor of ADAM17 as an active ingredient. The inhibitor is siRNA or antisense RNA.</p> |
