Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same

摘要

A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding hydroxyapatite (HAP) nanoparticles to form a uniformly distributed mixture, applying the mixture to a polytetrafluoroethylene (PTFE) surface to form a polymer film, cutting the polymer film into strips, stacking the strips with layers of bone particles disposed therebetween, coating the stacked strips and layers by the mixture and allowing it to dry, adding bone particles to the coating, and plasma treating the structure to form the biocompatible structure. A weight percentage of the HAP nanoparticles to the polymer is about 5-50% such that a resorption rate of the biocompatible structure substantially matches a rate of tissue generation in the biocompatible structure.

主权项

1. A biocompatible structure, comprising:
a plurality of polymer layers stacked to have a predetermined shape, wherein each of the polymer layers is formed with a polymer and first tissue forming nanoparticles, and a weight percentage of the first tissue forming nanoparticles to the polymer is about 0.5-95%; a plurality of bone particle layers disposed between each of the two neighboring polymer layers; a coating surrounding the plurality of polymer layers and bone particle layers; and a plurality of bone particles attached to an outer surface of the coating.