| 主权项 |
1. A method of attenuating hair loss in a human in need thereof comprising:
topically applying to skin comprising hair follicles of the human in need thereof a composition comprising:
an effective amount of a hair-loss attenuating peptide hydrolysate, wherein the peptide hydrolysate is produced from a protease hydrolysis of a protein-rich filtrate collected after cell disruption and elimination by centrifugation or filtration of most of the insoluble membrane components of a Saccharomyces yeast culture, wherein the protein-rich filtrate collected is thereafter adjusted to a generally neutral pH and hydrolyzed by a proteolytic enzyme, and wherein the peptide hydrolysate is composed of peptides each having a molecular weight of less than 6000 Daltons, anda cosmetically acceptable carrier;wherein the proteolytic enzyme is selected from papain, bromelain, and ficin or extracted from a microorganism selected from aspergillus, rhizopus, and bacillus; wherein the peptide hydrolysate increases the expression of keratin 14 in the external sheath cells of hair follicles, increases the expression of collagen IV in the wall of hair follicle blood vessels, increases the expression of protein CD34 in the wall of hair follicle blood vessels, and/or increases the expression of collagen I in the conjunctive tissue sheath and dermal papilla of the hair follicle. |
