主权项 |
1. A compound of Formula I:wherein:
R1 is alkyl or cycloalkyl, each of which can be unsubstituted or substituted with from one to four independently selected electron-donating or electron-withdrawing groups; R2, Rv and Rw are each independently hydrogen, alkyl, cycloalkyl, heterocyclo, aryl, or heteroaryl, which alkyl, cycloalkyl, heteroacylclo, aryl, or heteroaryl can be unsubstituted or substituted with from one to four independently selected electron-donating or electron-withdrawing groups, or R2, Rv and Rw are each independently an electron-donating or electron-withdrawing group; R3a, R3b and R4 are each independently hydrogen, an electron donating or electron-withdrawing group, or alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclo, heteroaryl, arylalkyl, heteroarylalkyl, or heterocycloalkyl, each of which can be unsubstituted or substituted with from one to four independently selected electron-donating or electron-withdrawing groups; R5 and R6 are each independently H or alkyl; and X′ is S or O; or a pharmaceutically acceptable salt or prodrug thereof. |