发明名称 |
METHODS OF DETECTING TUMOR CELLS |
摘要 |
In one aspect, methods of detecting tumor cells are described herein. In some embodiments, a method of detecting tumor cells comprises providing a device, the device comprising a substrate surface and a plurality of first aptamer probes attached to the substrate surface. The method further comprises contacting a plurality of cells with the plurality of first aptamer probes attached to the substrate surface; adhering one or more of the plurality of cells to the substrate surface; and measuring a non-uniformity parameter, a Hausdorff distance, a change in the number of pseudopods, and/or a shape of at least one adhered cell. In some cases, the method further comprises using the non-uniformity parameter, Hausdorff distance, change in the number of pseudopods, and/or shape of the adhered cell to identify the adhered cell as a tumor cell or a non-tumor cell. |
申请公布号 |
US2015010912(A1) |
申请公布日期 |
2015.01.08 |
申请号 |
US201414323840 |
申请日期 |
2014.07.03 |
申请人 |
Board of Regents, The University of Texas System |
发明人 |
Iqbal Samir M.;Goyal Swati;Kim Young-Tae;Wan Yuan;Mahmood Mohammed A.I.;Khan Umair J.M. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A method of detecting tumor cells comprising:
providing a device, the device comprising:
a substrate surface; anda plurality of first aptamer probes attached to the substrate surface; contacting a plurality of cells with the plurality of first aptamer probes attached to the substrate surface; adhering one or more of the plurality of cells to the substrate surface; and measuring a non-uniformity parameter, a Hausdorff distance, a change in the number of pseudopods, and/or a shape of at least one adhered cell. |
地址 |
Austin TX US |