ANTI-LIPOARABINOMANNAN ANTIBODY AND IMMUNOASSAY FOR MYCOBACTERIOSIS USING SAID ANTIBODY

摘要

The present invention provides a monoclonal antibody that specifically binds to acid-fast bacillary lipoarabinomannan, particularly tubercle bacillary lipoarabinomannan, the antibody being set forth below:
(A) a monoclonal antibody comprising a heavy chain variable region and a light chain variable region joined via a linker, the heavy chain variable region comprising heavy chains CDR1 to CDR3 shown in (a) to (c) below, and the light chain variable region comprising light chains CDR1 to CDR3 shown in (d) to (f) below:
(a) heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 1,
(b) heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 2,
(c) heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 3,
(d) light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 4,
(e) light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 5, and
(f) light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 6. The present invention further provides the use of the antibody.