发明名称 |
SUMOYLATION OF SERCA2A AND CARDIOVASCULAR DISEASE SERCA2A SUMO |
摘要 |
Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of SERCA2a post-translation modification such as SUMOylation or acetylation. Also provided are methods of treating cardiovascular disease by inhibiting SERCA2a degradation. Further provided are methods of diagnosing a propensity to develop heart failure comprising determining if a SERCA2a mutant is present or determining the level of expression of SUMO1 in cardiomyocytes. The disclosure also provides methods of screening for therapeutics that modulate the post-translational modification of SERCA2a, such as by modulating post-translational SUMOylation and/or acetylation. |
申请公布号 |
HK1197022(A1) |
申请公布日期 |
2015.01.02 |
申请号 |
HK20140110448 |
申请日期 |
2014.10.20 |
申请人 |
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发明人 |
HAJJAR, ROGER JOSEPH;KHO, CHANG WON;LEE, AH YOUNG |
分类号 |
A61K;C12N |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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