发明名称 |
METHOD FOR MANUFACTURING A SHAPED CROSS-LINKED HYALURONIC ACID PRODUCT |
摘要 |
A method for manufacturing a shaped cross-linked hyaluronic acid product is comprising the step of subjecting a non-cross-linked precipitated hyaluronic acid substrate in a desired shape to a single cross-linking reaction in a liquid mediumhaving a pH of 11.5 or higher and comprising one or more polyfunctional cross-linking agent(s) and anamount of one or more organic solvent(s) giving precipitating conditions for hyaluronic acid, under suitable conditions to obtain aprecipitated, shaped cross-linked hyaluronic acid product having a degree of modification of 1-40 cross-linking agent units per 1000 disaccharide units. |
申请公布号 |
WO2014206500(A1) |
申请公布日期 |
2014.12.31 |
申请号 |
WO2013EP63716 |
申请日期 |
2013.06.28 |
申请人 |
GALDERMA S.A. |
发明人 |
KARLSSON, MORGAN;HELANDER KENNE, ANNE;ÖHRLUND, ÅKE |
分类号 |
C08B37/08 |
主分类号 |
C08B37/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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