发明名称 |
COMBINATION THERAPY FOR A STABLE AND LONG TERM ENGRAFTMENT |
摘要 |
A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject. |
申请公布号 |
US2014363437(A1) |
申请公布日期 |
2014.12.11 |
申请号 |
US201214367917 |
申请日期 |
2012.12.20 |
申请人 |
Yeda Research and Development Co. Ltd. |
发明人 |
Reisner Yair;Bachar-Lustig Esther |
分类号 |
A61K35/28;A61K31/7076;A61K31/661;A61K39/395 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a subject in need of a non-syngeneic cell or tissue graft, the method comprising:
(a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein said T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein said dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein said therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject. |
地址 |
Rehovot IL |