3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives

摘要

The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic glutamate receptors subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and such compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

主权项

1. A compound of formula including any stereochemically isomeric form thereof, wherein R1 is C4-6alkyl, or C1-3alkyl substituted with C3-7cycloalkyl; R2 is hydrogen, halo or trifluoromethyl; R3 is hydrogen or C1-4alkyl substituted with hydroxyl; X is O or NH; n is an integer of value 1 or 2; or a pharmaceutically acceptable salt thereof.