发明名称 |
LOW MOLECULAR WEIGHT POLYETHYLENE GLYCOL DRUG CONJUGATES HAVING IMPROVED DRUG BIOLOGICAL ACTIVITY |
摘要 |
Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug. |
申请公布号 |
WO2014190763(A1) |
申请公布日期 |
2014.12.04 |
申请号 |
WO2014CN00550 |
申请日期 |
2014.06.03 |
申请人 |
JENKEM TECHNOLOGY CO., LTD. (TIANJIN) |
发明人 |
XU, LIHUA;ZHAO, XUAN;FENG, ZEWANG;WANG, JINLIANG;WANG, ZHENGUO |
分类号 |
A61K47/48;A61K31/382;A61K31/4045;A61K31/506;A61K47/34;A61P25/06;A61P27/06;A61P35/02 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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