发明名称 |
Preparation of aminomethyl furans and alkoxymethyl furan derivatives from carbohydrates |
摘要 |
Described herein are single step methods of making various classes of alkylamine derivatives of furan and tetrahydrofuran by simultaneous contact of a sugar with H2, an acid catalyst and hydrogenation catalyst in the presence of an alkylamide solvent. The hydrogenation catalyst is a heterogeneous catalyst comprising a metal selected from the group consisting of Pt, Pd, and nickel. The acid catalysts may be homogeneous mineral acid or a heterogeneous acid catalyst on substrate. In a preferred practice the two catalysts are provided on a common heterogeneous bifunctional support. Using similar combinations of acid and hydrogenation catalysts, there is also described single step methods for making furandimethanol by simultaneously contacting a hexose with the two separate catalysts in the presence of H2 in an aprotic solvent, such as dimethylformamide. With the same catalyst system and similar reaction conditions, 2, 5 furan dialkylethers can also be made in a single step when the solvent includes an ROH alcohol. |
申请公布号 |
US8901326(B2) |
申请公布日期 |
2014.12.02 |
申请号 |
US201314085080 |
申请日期 |
2013.11.20 |
申请人 |
Archer Daniels Midland Company |
发明人 |
Howard Stephen;Sanborn Alexandra |
分类号 |
C07D307/04;C07D307/34;C07D307/42;C07D307/14;C07D307/12;C07D307/44;C07D307/52 |
主分类号 |
C07D307/04 |
代理机构 |
|
代理人 |
Sanborn Alexandra;Roberts Mark W. |
主权项 |
1. A method for making a 2,5-dihydroxymethylfuran or a 2,5-dihydroxymethyl tetrahydrofuran derivative compound of a formula selected from the group consisting of: where R is H or a C1-C4 alkyl group; comprising, contacting the hexose in an organic solvent with a hydrogenation catalyst containing a metal comprising a member selected from the group consisting of Pd, Pt and Ni, and simultaneously with an acid catalyst, at a temperature, a pressure and for a time sufficient to dehydrate the sugar and reduce the dehydrated product to the hydroxymethylfuran or hydroxymethyltetrahydrofuran derivative. |
地址 |
Decatur IL US |