Cyclic amide derivative

摘要

Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is C6-10 arylene, etc.; R1a, R1b and R1c each independently is a hydrogen atom, a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, etc.; R2 is an optionally substituted C6-10 aryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted C7-16 aralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.);

主权项

1. A compound of formula (1), or a pharmaceutically acceptable salt thereof:[wherein A is C6-10 arylene, or 5- or 6-membered monocyclic heteroarylene selected from the group of the following group: R1a, R1b and R1c are each independently, (1) hydrogen atom, (2) deuterium atom, (3) halogen atom, (4) cyano group, (5) C1-4 alkyl group (in which the group may be optionally substituted by
(a) 1 to 3 halogen atom(s),(b) C1-4 alkoxy (in which the group may be optionally substituted by 1 to 3 halogen atom(s)),(c) C3-6 cycloalkyl,(d) C3-6 cycloalkoxy, or(e) heterocycle), (6) C1-4 alkoxy group (in which the group may be optionally substituted by
(a) 1 to 3 halogen atom(s),(b) C1-4 alkoxy (in which the group may be optionally substituted by 1 to 3 halogen atom(s)),(c) C3-6 cycloalkyl, or(d) C3-6 cycloalkoxy), (7) C3-6 cycloalkyl group, (8) C3-6 cycloalkoxy group, (9) heterocyclic oxy group, or (10) C7-16 aralkyloxy group; R2 is optionally substituted C6-10 aryl group, optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, optionally substituted C7-16 aralkyl group, optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl-C1-6 alkyl group, optionally substituted heterocycle group, or C1-6 alkyl group (in which the alkyl group may be optionally substituted by optionally substituted C6-10 aryloxy);
m is 0 or 1;n is an integer of 0 to 2.]