| 摘要 |
The present invention relates to an inhibitor of Adenosine-monophosphate-activated kinase (AMPK) inactivation and to said inhibitor of AMPK inactivation for use in preventing and/or treating disease, particularly a disease selected from the list consisting of cancer cachexia, non- tumor-cachexiae, lipodystrophy, metabolic syndrome, and diabetes type I. The present invention further relates to a polynucleotide encoding an inhibitor of AMPK inactivation and to a device and to a kit comprising the inhibitor of AMPK inactivation according to the present invention. The invention also relates to a use of an inhibitor of AMPK inactivation for preventing and/or treating cancer cachexia, a non-tumor-cachexia, lipodystrophy, metabolic syndrome, or diabetes type I; to a method for predicting and/or diagnosing cancer cachexia in a subject afflicted with cancer; to a method for identifying a compound for treating or preventing cancer cachexia; and to a pharmaceutical composition comprising the inhibitor of AMPK inactivation of the present invention. |
