Click chemistry on heterogeneous catalysts

摘要

The present invention relates to new methods and reagents for coupling molecules by a Click reaction using a heterogeneous catalyst system. Further, the present invention refers to novel devices for carrying out Click reactions.

主权项

1. A method of coupling a first molecule to a second molecule by a Click reaction, comprising contacting the first molecule comprising a first Click functional group, which is an alkyne group, and the second molecule comprising a second complementary Click functional group, which is an azide group capable of reacting with the first Click-functional group by a Click reaction, in the presence of a heterogeneous Cu—C catalyst under conditions wherein the Click reaction between the first and second molecule occurs wherein one of the first and second molecules is immobilized on a dry solid carrier thereby pre-impregnating the solid carrier, and contacting the dry solid carrier pre-impregnated with one of the first and second molecules with a liquid medium comprising the other molecule, wherein the solid carrier is the heterogeneous Cu—C catalyst.