Methods and Compositions for Determining a Graft Tolerant Phenotype in a Subject

摘要

Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression of at least 5 genes in a sample from the subject, e.g., a blood sample, is assayed to obtain a gene expression result for the at least 5 genes. The obtained gene expression result for the at least 5 genes is then employed to determine whether the subject has a graft tolerant phenotype. Also provided are compositions, systems and kits that find use in practicing the subject methods. The methods and compositions find use in a variety of applications, including the determination of an immunosuppressive therapy regimen.

主权项

1. A method of determining whether a subject who has received an allograft has a graft tolerant phenotype, said method comprising:
(a) evaluating the level of expression of at least 5 genes in a sample from said subject to obtain a gene expression result, wherein said at least 5 genes are selected from either Table 2 or Table 4; and (b) determining whether said subject has a graft tolerant phenotype based on said gene expression result.