METHOD FOR IMPROVING THE SUCCESS RATE OF HEMATOPOIETIC STEM CELL TRANSPLANTS

摘要

The technology described herein relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the genes encoding negative regulators of MHC expansion (e.g. AhR, Itch, Prox1 and/or SH2B3), and methods of using such dsRNA compositions to inhibit expression of negative regulators of MHC expansion. The use of such compositions to provide, for example, enhanced quantitites and/or qualities of MHCs and/or hematopoietic progenitor cells for transplantation and/or to enhance engraftment of transplanted MHCs hematopoietic progenitor cells is described.

主权项

1. A double-stranded ribonucleic acid (dsRNA) that inhibits expression of a gene encoding a negative regulator of multipotent hematopoietic cell (MHC) expansion, wherein said negative regulator of MHC expansion is gene selected from the group consisting of: Itch, SH2B3, Prox1 and AhR.